The purpose of the panel is to systematize Karl Marx's most relevant ideas for the 21st century and to show how classic and modern Marxist methodology can ve used for the analysis and solvation of the major problems of the 21st century. Among them: 1) Capitalism is coming back: desocialization and rebirth of the class conflicts of the capital and labour. Marxist alternative. 2) Marx’s analysis of market and money and modern market of simulacra. 3) Deepening conflicts: 21st century and rebirth of dialectical method. 4) Marx’s theory of disalienation and problems of development of a strategy for social liberation.